Organophotoelectrocatalytic C(sp²)–H alkylation of heteroarenes with unactivated C(sp³)–H compounds

An organophotoelectrocatalytic method for the C(sp²)–H alkylation of heteroarenes with unactivated C(sp³)–H compounds through dehydrogenation cross-coupling has been developed. The C(sp²)–H alkylation combines organic catalysis, photochemistry and electrochemistry, avoiding the need for external metal-reagents, HAT-reagents, and oxidants. This protocol exhibits good substrate tolerance and functional group compatibility, providing a straightforward and powerful pathway to access a variety of alkylated heteroarenes under green conditions.