Issue 34, 2010
From the journal:

Chemical Communications

Structural insights into substrate specificity and solvent tolerance in alcohol dehydrogenaseADH-‘A’ from Rhodococcus ruberDSM 44541†‡

Martin Karabec,a   Andrzej Łyskowski,a   Katharina C. Tauber,b   Georg Steinkellner,c   Wolfgang Kroutil,b   Gideon Grogan*d  and  Karl Gruber*a  

* Corresponding authors

a Institute of Molecular Biosciences, University of Graz, Humboldtstrasse 50/3, A-8010 Graz, Austria
E-mail: karl.gruber@uni-graz.at
Fax: +43 316 380 9897
Tel: +43 316 380 5483

b Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria

c Austrian Centre of Industrial Biotechnology, Petersgasse 14, A-8010 Graz, Austria

d York Structural Biology Laboratory, Department of Chemistry, University of York, YO10 5YW York, UK
E-mail: grogan@ysbl.york.ac.uk
Fax: +44 (0)1904 328266
Tel: +44 (0)1904 328256

Abstract

The structure of the alcohol dehydrogenase ADH-‘A’ from Rhodococcus ruber reveals possible reasons for its remarkable tolerance to organic co-solvents and suggests new directions for structure-informed mutagenesis to produce enzymes of altered substrate specificity or improved selectivity.

Graphical abstract: Structural insights into substrate specificity and solvent tolerance in alcohol dehydrogenase ADH-‘A’ from Rhodococcus ruber DSM 44541

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C0CC00929F
Article type
Communication
Submitted
14 Apr. 2010
Accepted
09 Jūl. 2010
First published
02 Aug. 2010

Chem. Commun., 2010,46, 6314-6316

Permissions

Request permissions

Structural insights into substrate specificity and solvent tolerance in alcohol dehydrogenase ADH-‘A’ from Rhodococcus ruber DSM 44541

M. Karabec, A. Łyskowski, K. C. Tauber, G. Steinkellner, W. Kroutil, G. Grogan and K. Gruber, Chem. Commun., 2010, 46, 6314 DOI: 10.1039/C0CC00929F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements