Issue 46, 2010
From the journal:

Chemical Communications

Comparing dendritic with linear esterase peptides by screening SPOT arrays for catalysis†‡

Rasomoy Biswas,a   Noélie Maillard,a   Jacob Kofoedb  and  Jean-Louis Reymond*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of Berne, Freiestrasse 3, CH-3012 Berne, Switzerland
E-mail: jean-louis.reymond@ioc.unibe.ch
Fax: +41 31 631 80 57
Tel: +41 31 631 43 25

b Novo Nordisk A/S, Novo Nordisk Park, 2760 Maaloev, Denmark

Abstract

Fluorescence screening of a 96-membered SPOT library of histidine containing dendritic and linear peptides revealed the remarkable esterolytic activity of short histidine oligomers that show catalytic proficiencies within one order of magnitude of histidine-containing esterase peptide dendrimers.

Graphical abstract: Comparing dendritic with linear esterase peptides by screening SPOT arrays for catalysis

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Article information

DOI
https://doi.org/10.1039/C0CC02700F
Article type
Communication
Submitted
21 Jūl. 2010
Accepted
04 Okt. 2010
First published
21 Okt. 2010

Chem. Commun., 2010,46, 8746-8748

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Comparing dendritic with linear esterase peptides by screening SPOT arrays for catalysis

R. Biswas, N. Maillard, J. Kofoed and J. Reymond, Chem. Commun., 2010, 46, 8746 DOI: 10.1039/C0CC02700F

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