68Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers

Brandon Nichols; Zhengtao Qin; Jun Yang; David R. Vera; Neal K. Devaraj

doi:10.1039/C3CC49530B

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⁶⁸Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers†

Brandon Nichols,‡^a Zhengtao Qin,‡^b Jun Yang,^a David R. Vera*^b and Neal K. Devaraj*^a

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* Corresponding authors

^a Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA
E-mail: ndevaraj@ucsd.edu

^b Department of Radiology, UCSD In Vivo Cancer and Molecular Imaging Center, University of California, San Diego, La Jolla, CA, USA
E-mail: dvera@ucsd.edu

Abstract

We have developed a ⁶⁸Ga metal chelating bioorthogonal tetrazine dextran probe that is highly reactive with trans-cyclooctene modified monoclonal antibodies for multistep imaging applications. Confocal microscopy and positron emission tomography (PET) were used to characterize the dextran probe in vitro and in vivo.

This article is part of the themed collection: 2014 Emerging Investigators

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Article information

DOI: https://doi.org/10.1039/C3CC49530B
Article type: Communication
Submitted: 16 Dec. 2013
Accepted: 19 Febr. 2014
First published: 21 Febr. 2014

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Chem. Commun., 2014,50, 5215-5217

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⁶⁸Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers

B. Nichols, Z. Qin, J. Yang, D. R. Vera and N. K. Devaraj, Chem. Commun., 2014, 50, 5215 DOI: 10.1039/C3CC49530B

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