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In situ 31P solid-state NMR studies of halogen bond formation between triphenylphosphine oxide and para-diiodotetrafluorobenzene provide insights into the cocrystallisation process and provide an estimate of the activation energy. The effects of temperature, magic-angle spinning speed, and initially added liquid on the reaction rate and mechanism have been investigated.

Graphical abstract: A kinetic study of mechanochemical halogen bond formation by in situ31P solid-state NMR spectroscopy

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