Issue 8, 2017
From the journal:

CrystEngComm

Self-templating accelerates precipitation of carbamazepine dihydrate during the dissolution of a soluble carbamazepine cocrystal†

Hiroyuki Yamashitaab  and  Changquan Calvin Sun ORCID logo *b  

* Corresponding authors

a Analytical Research Laboratories, Technology, Astellas Pharma Inc., Tsukuba-shi, Ibaraki, Japan

b Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
E-mail: sunx0053@umn.edu

Abstract

Similarly organized carbamazepine (CBZ) clusters in a soluble cocrystal with glutaric acid templated the nucleation and precipitation of poorly soluble CBZ dihydrate during dissolution.

Graphical abstract: Self-templating accelerates precipitation of carbamazepine dihydrate during the dissolution of a soluble carbamazepine cocrystal

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Article information

DOI
https://doi.org/10.1039/C6CE02418A
Article type
Communication
Submitted
21 Nov. 2016
Accepted
06 Janv. 2017
First published
11 Janv. 2017

CrystEngComm, 2017,19, 1156-1159

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Self-templating accelerates precipitation of carbamazepine dihydrate during the dissolution of a soluble carbamazepine cocrystal

H. Yamashita and C. C. Sun, CrystEngComm, 2017, 19, 1156 DOI: 10.1039/C6CE02418A

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