Spatially resolved coding of λ-orthogonal hydrogels by laser lithography

Rhiannon R. Batchelor; Eva Blasco; Kilian N. R. Wuest; Hongxu Lu; Martin Wegener; Christopher Barner-Kowollik; Martina H. Stenzel

doi:10.1039/C7CC09619D

Spatially resolved coding of λ-orthogonal hydrogels by laser lithography†

Rhiannon R. Batchelor,^a Eva Blasco,

^b Kilian N. R. Wuest,^b Hongxu Lu,

^a Martin Wegener,^cd Christopher Barner-Kowollik

*^be and Martina H. Stenzel

*^a

Author affiliations

* Corresponding authors

^a Centre for Advanced Macromolecular Design, School of Chemistry, University of New South Wales (UNSW), Sydney, Australia
E-mail: m.stenzel@unsw.edu.au

^b Macromolecular Architectures, Institut für Technische Chemie und Polymerchemie, Karlsruhe Institute of Technology (KIT), Engesserstr. 18, 76131 Karlsruhe, Germany
E-mail: Christopher.barner-kowollik@kit.edu

^c Institute of Applied Physics, Karlsruhe Institute of Technology (KIT), Wolfgang-Gaede-Straße 1, 76128 Karlsruhe, Germany

^d Institute of Nanotechnology, Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany

^e School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology (QUT), 2 George Street, Brisbane, QLD 4000, Australia
E-mail: christopher.barnerkowollik@qut.edu.au

Abstract

A λ-orthogonal reaction system is introduced, where visible light induced radical thiol–ene and UV light induced NITEC (Nitrile-Imine mediated Tetrazole–Ene Conjugation) ligations are consecutively employed to fabricate and functionalize PEG-based hydrogels. The fluorescent pyrazoline cycloadducts from the NITEC reaction are exploited to visualize the written structures within the hydrogels as well as to attach RGD containing functional groups to promote spatially resolved cell attachment on the hydrogel surface.

This article is part of the themed collection: Celebrating Excellence in Research: 100 Women of Chemistry

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DOI: https://doi.org/10.1039/C7CC09619D
Article type: Communication
Submitted: 15 Dec. 2017
Accepted: 07 Febr. 2018
First published: 19 Febr. 2018

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Chem. Commun., 2018,54, 2436-2439

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Spatially resolved coding of λ-orthogonal hydrogels by laser lithography

R. R. Batchelor, E. Blasco, K. N. R. Wuest, H. Lu, M. Wegener, C. Barner-Kowollik and M. H. Stenzel, Chem. Commun., 2018, 54, 2436 DOI: 10.1039/C7CC09619D

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Chemical Communications

Spatially resolved coding of λ-orthogonal hydrogels by laser lithography†

Abstract

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Spatially resolved coding of λ-orthogonal hydrogels by laser lithography

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