Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system

Zeng-Fei Pei; Min-Jie Yang; Lei Li; Xiao-Hong Jian; Yue Yin; Dehai Li; Hai-Xue Pan; Yinhua Lu; Weihong Jiang; Gong-Li Tang

doi:10.1039/C8OB02665C

Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system†

Zeng-Fei Pei,‡^a Min-Jie Yang,‡^a Lei Li,‡^b Xiao-Hong Jian,^a Yue Yin,^a Dehai Li,

^c Hai-Xue Pan,^a Yinhua Lu,^d Weihong Jiang*^b and Gong-Li Tang

*^a

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* Corresponding authors

^a State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, China
E-mail: gltang@sioc.ac.cn

^b Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
E-mail: whjiang@sibs.ac.cn

^c Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China

^d School of Life and Environmental Sciences, Shanghai Normal University, Shanghai, China

Abstract

Using a highly effective heterologous expression system, the YM-216391 (1) biosynthetic gene cluster was engineered to yield aurantizolicin (2) and the hybrid compound 3. Both of these compounds were isolated and fully structurally characterised and the bioactivity was evaluated. The results indicate that compound 3 exhibits significantly improved antitumor activity.

This article is part of the themed collections: Chemical Biology in OBC and Biosynthesis

Organic & Biomolecular Chemistry

Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system†

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Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system

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