Visible-light-promoted 3,5-dimethoxyphenyl glycoside activation and glycosylation

Yafei Cao; Minmin Zhou; Run-Ze Mao; You Zou; Feng Xia; Da-Ke Liu; Jianhui Liu; Qin Li; De-Cai Xiong; Xin-Shan Ye

doi:10.1039/D1CC04473G

Visible-light-promoted 3,5-dimethoxyphenyl glycoside activation and glycosylation†

Yafei Cao,‡^a Minmin Zhou,‡^ab Run-Ze Mao,^a You Zou,^a Feng Xia,^a Da-Ke Liu,^a Jianhui Liu,^b Qin Li,^a De-Cai Xiong*^ac and Xin-Shan Ye

*^a

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^a State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road No. 38, Beijing 100191, China
E-mail: xinshan@bjmu.edu.cn, decai@bjmu.edu.cn

^b School of Chemical Engineering, Dalian University of Technology, Dalian 116024, Liaoning, China

^c State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, Jiangsu, China

Abstract

A new glycosylation method promoted by visible light with 3,5-dimethoxyphenyl glycoside as the donor was developed. This protocol delivers both O-glycosides and N-glycosides in moderate to excellent yields using a wide range of O-nucleophiles and nucleobases as the glycosyl acceptors.

This article is part of the themed collection: Functionalization of unreactive C-H bonds

Chemical Communications

Visible-light-promoted 3,5-dimethoxyphenyl glycoside activation and glycosylation†

Abstract

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Visible-light-promoted 3,5-dimethoxyphenyl glycoside activation and glycosylation

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