Issue 6, 2023
From the journal:

New Journal of Chemistry

Selenylated indoles: synthesis, effects on lipid membrane properties and DNA cleavage†

Gabriela J. Pedroso,a   Desirée M. S. Costa,b   Lucas T. Felipe Kokuszi, ORCID logo b   Eduardo B. V. da Silva,b   Marcos F. O. Cavalcante,c   Eduardo Junca,d   Cassio A. O. Moraes,e   Claus T. Pich, ORCID logo a   Vânia R. de Lima,b   Sumbal Saba,c   Jamal Rafique ORCID logo *ce  and  Tiago E. A. Frizon ORCID logo *a  

* Corresponding authors

a Department of Energy and Sustainability, Federal University of Santa Catarina, Araranguá, SC, Brazil
E-mail: tiago.frizon@ufsc.br

b Escola de Química e Alimentos, Programa de Pós-Graduação em Química Tecnológica e Ambiental, Universidade Federal do Rio Grande, RS, Brazil

c Instituto de Química, Universidade Federal de Goiás, Goiânia, GO, Brazil

d University of the Extreme South of Santa Catarina (UNESC), Criciúma, SC, Brazil

e Institute of Chemistry, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil
E-mail: jamal.rafique@ufms.br, jamal.chm@gmail.com
Web: https://sintmol.ufms.br/

Abstract

In this report, we evaluated the effects of selenylated indoles (3a–d) on lipid membranes and their capacity to interact with DNA. These selenylated indoles increased the motion rate of the polar region of lipids and compounds 3b–d ordered the non-polar region. The DNA cleavage ability was observed only for 3c.

Graphical abstract: Selenylated indoles: synthesis, effects on lipid membrane properties and DNA cleavage

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Article information

DOI
https://doi.org/10.1039/D2NJ04330K
Article type
Paper
Submitted
30 Aug. 2022
Accepted
12 Dec. 2022
First published
13 Dec. 2022

New J. Chem., 2023,47, 2719-2726

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Selenylated indoles: synthesis, effects on lipid membrane properties and DNA cleavage

G. J. Pedroso, D. M. S. Costa, L. T. Felipe Kokuszi, E. B. V. da Silva, M. F. O. Cavalcante, E. Junca, C. A. O. Moraes, C. T. Pich, V. R. de Lima, S. Saba, J. Rafique and T. E. A. Frizon, New J. Chem., 2023, 47, 2719 DOI: 10.1039/D2NJ04330K

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