Issue 10, 2024
From the journal:

Analytical Methods

In situ setup for screening of drug permeation by NMR spectroscopy†

Malte Mildner,‡a   Simon Hanio, ORCID logo ‡b   Sebastian Endres,a   Lena Scheller, ORCID logo b   Bettina Engel,b   Laura Castañar, ORCID logo c   Lorenz Meinel ORCID logo b  and  Ann-Christin Pöppler ORCID logo *a  

* Corresponding authors

a Institute of Organic Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany
E-mail: ann-christin.poeppler@uni-wuerzburg.de

b Institute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany

c Department of Organic Chemistry, Faculty of Chemical Science, Complutense University of Madrid, Madrid, Spain

Abstract

There are various commercially available setups for studying drug permeation, which differ in cost and manual labor. We explore an artificial membrane in an NMR tube to assess drug permeation with automated measurements. NMR-based concentrations were validated with HPLC and compared to a conventional setup. Setup-specific challenges and workarounds as well as future setup-designs for this and other applications are discussed.

Graphical abstract: In situ setup for screening of drug permeation by NMR spectroscopy

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Article information

DOI
https://doi.org/10.1039/D3AY01995K
Article type
Communication
Submitted
11 Nov. 2023
Accepted
30 Dec. 2023
First published
08 Janv. 2024

Anal. Methods, 2024,16, 1468-1472

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In situ setup for screening of drug permeation by NMR spectroscopy

M. Mildner, S. Hanio, S. Endres, L. Scheller, B. Engel, L. Castañar, L. Meinel and A. Pöppler, Anal. Methods, 2024, 16, 1468 DOI: 10.1039/D3AY01995K

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