Issue 17, 2010
From the journal:

Chemical Communications

An unnatural amino acid that mimics phosphotyrosine†

Jingyan Ge,a   Hao Wub  and  Shao Q. Yao*abc  

* Corresponding authors

a Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543

b Department of Biological Sciences, National University of Singapore, 3 Science Drive 3, Singapore 117543

c NUS MedChem Program of the Life Sciences Institute, National University of Singapore, 3 Science Drive 3, Singapore 117543
E-mail: chmyaosq@nus.edu.sg
Fax: (+65) 67791691
Tel: (+65) 65162925

Abstract

By replacing the phosphate group in pTyr with an isoxazole carboxylic acid, a novel unnatural amino acid has been successfully synthesized. Subsequently, its incorporation into a known PPI (protein–protein interaction) inhibitor of STAT3 protein (ISS 610) generated I2 which showed reasonable anti-STAT3 activity in both fluorescence polarization and cell-proliferation experiments.

Graphical abstract: An unnatural amino acid that mimics phosphotyrosine

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Article information

DOI
https://doi.org/10.1039/C000283F
Article type
Communication
Submitted
06 Janv. 2010
Accepted
13 Febr. 2010
First published
05 Marts 2010

Chem. Commun., 2010,46, 2980-2982

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An unnatural amino acid that mimics phosphotyrosine

J. Ge, H. Wu and S. Q. Yao, Chem. Commun., 2010, 46, 2980 DOI: 10.1039/C000283F

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