Issue 37, 2010
From the journal:

Chemical Communications

Interaction of PqqE and PqqD in the pyrroloquinoline quinone (PQQ) biosynthetic pathway links PqqD to the radical SAM superfamily†‡

Stephen R. Wecksler,a   Stefan Stoll,b   Anthony T. Iavarone,a   Erin M. Imsand,a   Ha Tran,a   R. David Brittb  and  Judith P. Klinman*a  

* Corresponding authors

a Department of Chemistry, Department of Molecular and Cell Biology, and the California Institute for Quantitative Biosciences, University of California, Berkeley, USA
E-mail: klinman@berkeley.edu
Fax: +1 510 643 6232
Tel: +1 510 642 2668

b Department of Chemistry, University of California, Davis, USA
E-mail: rdbritt@ucdavis.edu
Fax: +1 530 752 8995
Tel: +1 530 752 6377

Abstract

pqqD is one of six genes required for PQQ production in Klebsiella pneumoniae. Herein, we demonstrate that PqqD interacts specifically with the radical SAM enzyme PqqE, causing a perturbation in the electronic environment around the [4Fe–4S]+ clusters. This interaction redirects the role for PqqD in PQQ biosynthesis.

Graphical abstract: Interaction of PqqE and PqqD in the pyrroloquinoline quinone (PQQ) biosynthetic pathway links PqqD to the radical SAM superfamily

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Article information

DOI
https://doi.org/10.1039/C0CC00968G
Article type
Communication
Submitted
15 Apr. 2010
Accepted
16 Jūl. 2010
First published
25 Aug. 2010

Chem. Commun., 2010,46, 7031-7033

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Interaction of PqqE and PqqD in the pyrroloquinoline quinone (PQQ) biosynthetic pathway links PqqD to the radical SAM superfamily

S. R. Wecksler, S. Stoll, A. T. Iavarone, E. M. Imsand, H. Tran, R. D. Britt and J. P. Klinman, Chem. Commun., 2010, 46, 7031 DOI: 10.1039/C0CC00968G

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