Issue 43, 2010

Phage display selection of miniprotein binders of the Estrogen Receptor

Abstract

Miniprotein phage display screening yields structured peptides with high affinity for the Estrogen Receptor (ER). Hits from apamin phage libraries feature a LXXLL motif specifically placed on the predefined miniprotein helical segment. The apamin scaffold also allows optimization of flanking amino acids to ensure an optimal ER binding affinity.

Graphical abstract: Phage display selection of miniprotein binders of the Estrogen Receptor

Supplementary files

Article information

Article type
Communication
Submitted
22 Jūl. 2010
Accepted
10 Sept. 2010
First published
27 Sept. 2010

Chem. Commun., 2010,46, 8207-8209

Phage display selection of miniprotein binders of the Estrogen Receptor

T. Phan, H. D. Nguyen, H. Göksel, S. Möcklinghoff and L. Brunsveld, Chem. Commun., 2010, 46, 8207 DOI: 10.1039/C0CC02727H

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