Issue 47, 2010
From the journal:

Chemical Communications

Photochemical cleavage of leader peptides†‡

Noah Bindman,a   Remco Merkx,a   Robert Koehler,a   Nicholas Herrmana  and  Wilfred A. van der Donk*a  

* Corresponding authors

a Department of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, 600 S Mathews Ave, Urbana, USA
E-mail: vddonk@uiuc.edu
Fax: +1 217 244-8533
Tel: +1 217 244-5360

Abstract

We report a photolabile linker compatible with Fmoc solid phase peptide synthesis and Cu(I)-catalyzed alkyne–azide cycloaddition that allows photochemical cleavage to afford a C-terminal peptide fragment with a native amino terminus.

Graphical abstract: Photochemical cleavage of leader peptides

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C0CC02945A
Article type
Communication
Submitted
01 Aug. 2010
Accepted
14 Okt. 2010
First published
02 Nov. 2010

Chem. Commun., 2010,46, 8935-8937

Permissions

Request permissions

Photochemical cleavage of leader peptides

N. Bindman, R. Merkx, R. Koehler, N. Herrman and W. A. van der Donk, Chem. Commun., 2010, 46, 8935 DOI: 10.1039/C0CC02945A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements