Issue 6, 2011
From the journal:

Nanoscale

Differential nano-bio interactions and toxicity effects of pristine versus functionalized graphene†

Abhilash Sasidharan,a   L. S. Panchakarla,b   Parwathy Chandran,a   Deepthy Menon,a   Shantikumar Nair,*a   C. N. R. Raob  and  Manzoor Koyakutty*a  

* Corresponding authors

a Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Cochin, Kerala, India
E-mail: manzoork@aims.amrita.edu, shantinair@aims.amrita.edu

b International Centre for Materials Science, Chemistry and Physics of Materials Unit, C. S. I. R. Centre of Excellence in Chemistry, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur P.O., Bangalore, India

Abstract

We report the effect of carboxyl functionalization of graphene in pacifying its strong hydrophobic interaction with cells and associated toxic effects. Pristine graphene was found to accumulate on the cell membrane causing high oxidative stress leading to apoptosis, whereas carboxyl functionalized hydrophilic graphene was internalized by the cells without causing any toxicity.

Graphical abstract: Differential nano-bio interactions and toxicity effects of pristine versus functionalized graphene

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Article information

DOI
https://doi.org/10.1039/C1NR10172B
Article type
Communication
Submitted
14 Febr. 2011
Accepted
15 Apr. 2011
First published
12 Maijs 2011

Nanoscale, 2011,3, 2461-2464

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Differential nano-bio interactions and toxicity effects of pristine versus functionalized graphene

A. Sasidharan, L. S. Panchakarla, P. Chandran, D. Menon, S. Nair, C. N. R. Rao and M. Koyakutty, Nanoscale, 2011, 3, 2461 DOI: 10.1039/C1NR10172B

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