Issue 22, 2012
From the journal:

RSC Advances

Highly fluorescent benzofuran derivatives of the GFP chromophore†

Mikkel Andreas Christensen,a   Karsten Jennum,a   Peter Bæch Abrahamsen,a   Eduardo Antonio Della Pia,a   Kasper Lincke,a   Søren Lindbæk Broman,a   David Bo Nygaard,a   Andrew D. Bondb  and  Mogens Brøndsted Nielsen*a  

* Corresponding authors

a Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen Ø, Denmark
E-mail: mbn@kiku.dk
Fax: +45 3532 0212
Tel: +45 3532 0210

b Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark

Abstract

Intramolecular cyclization reactions of Green Fluorescent Protein chromophores (GFPc) containing an arylethynyl ortho-substituent at the phenol ring provide new aryl-substituted benzofuran derivatives of the GFPc. Some of these heteroaromatic compounds exhibit significantly enhanced fluorescence at red-shifted emission wavelengths relative to the parent GFPc structure.

Graphical abstract: Highly fluorescent benzofuran derivatives of the GFP chromophore

  • This article is part of the themed collection: Aromaticity
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Article information

DOI
https://doi.org/10.1039/C2RA21380J
Article type
Communication
Submitted
06 Jūl. 2012
Accepted
11 Jūl. 2012
First published
13 Jūl. 2012

RSC Adv., 2012,2, 8243-8249

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Highly fluorescent benzofuran derivatives of the GFP chromophore

M. A. Christensen, K. Jennum, P. B. Abrahamsen, E. A. D. Pia, K. Lincke, S. L. Broman, D. B. Nygaard, A. D. Bond and M. B. Nielsen, RSC Adv., 2012, 2, 8243 DOI: 10.1039/C2RA21380J

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