Issue 1, 2015
From the journal:

Biomaterials Science

MMP9-sensitive polymers mediate environmentally-responsive bivalirudin release and thrombin inhibition†

D. S. Chu,‡a   D. L. Sellers,‡b   M. J. Bocek,a   A. E. Fischedick,b   P. J. Horner*b  and  S. H. Pun*a  

* Corresponding authors

a Department of Bioengineering and Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA 98195, USA
E-mail: spun@u.washington.edu
Fax: (+)1-206-685-3488

b Department of Neurological Surgery and Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA
E-mail: phorner@u.washington.edu

Abstract

MMP9-responsive bivalirudin-HPMA copolymers were synthesized for direct, local administration in rat spinal cord contusion injury models. Polymer-conjugated bivalirudin peptides maintained activity while demonstrating enzyme-mediated release upon MMP9 exposure and prolonged release from hyaluronic acid/methylcellulose (HAMC) hydrogels compared to free bivalirudin peptide. Localized administration of bivalirudin copolymers in vivo at the site of rat spinal cord injury decreased cellular proliferation and astrogliosis, suggesting the bivalirudin copolymer and HAMC hydrogel system are a promising therapeutic intervention for reducing immediate inflammatory responses and long term scarring.

Graphical abstract: MMP9-sensitive polymers mediate environmentally-responsive bivalirudin release and thrombin inhibition

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4BM00259H
Article type
Communication
Submitted
24 Jūl. 2014
Accepted
22 Aug. 2014
First published
08 Sept. 2014

Biomater. Sci., 2015,3, 41-45

Permissions

Request permissions

MMP9-sensitive polymers mediate environmentally-responsive bivalirudin release and thrombin inhibition

D. S. Chu, D. L. Sellers, M. J. Bocek, A. E. Fischedick, P. J. Horner and S. H. Pun, Biomater. Sci., 2015, 3, 41 DOI: 10.1039/C4BM00259H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements