Redox-responsive self-assembled chain-shattering polymeric therapeutics

Kaimin Cai; Jonathan Yen; Qian Yin; Yang Liu; Ziyuan Song; Stéphane Lezmi; Yanfeng Zhang; Xujuan Yang; William G. Helferich; Jianjun Cheng

doi:10.1039/C4BM00452C

Redox-responsive self-assembled chain-shattering polymeric therapeutics†

Kaimin Cai,^a Jonathan Yen,^b Qian Yin,^a Yang Liu,^a Ziyuan Song,^a Stéphane Lezmi,^c Yanfeng Zhang,^a Xujuan Yang,^d William G. Helferich*^d and Jianjun Cheng*^ab

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* Corresponding authors

^a Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA
E-mail: jianjunc@illinois.edu

^b Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

^c Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

^d Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA
E-mail: helferic@illinois.edu

Abstract

We report the design and development of redox-responsive chain-shattering polymeric therapeutics (CSPTs). CSPTs were synthesized by condensation polymerization and further modified with poly(ethylene glycol) (PEG) via “Click” reaction. Size-controlled CSPT nanoparticles (NPs) were formed through nanoprecipitation with high drug loading (up to 18%); the particle size increased in a concentration dependent manner. Drug release from particles was well controlled over 48 h upon redox triggering. The anticancer efficacy of the CSPT NPs was validated both in vitro and in vivo.

This article is part of the themed collection: Polymeric biomaterials for cancer nanotechnology

Biomaterials Science

Redox-responsive self-assembled chain-shattering polymeric therapeutics†

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