Unprecedented staining of polar lipids by a luminescent rhenium complex revealed by FTIR microspectroscopy in adipocytes

C. A. Bader; E. A. Carter; A. Safitri; P. V. Simpson; P. Wright; S. Stagni; M. Massi; P. A. Lay; D. A. Brooks; S. E. Plush

doi:10.1039/C6MB00242K

Unprecedented staining of polar lipids by a luminescent rhenium complex revealed by FTIR microspectroscopy in adipocytes†

C. A. Bader,^a E. A. Carter,^b A. Safitri,^b P. V. Simpson,^c P. Wright,^c S. Stagni,^d M. Massi,^c P. A. Lay,^b D. A. Brooks^a and S. E. Plush*^a

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* Corresponding authors

^a Mechanisms in Cell Biology and Disease Research Group, School of Pharmacy and Medical Sciences/Sansom Institute for Health Research, University of South Australia, Adelaide, Australia
E-mail: sally.plush@unisa.edu.au

^b Vibrational Spectroscopy Core Facility and School of Chemistry, The University of Sydney, Sydney, Australia

^c School of Chemistry, Curtin University, Perth, Australia

^d Department of Industrial Chemistry “Toso Montanari”, University of Bologna, Bologna, Italy

Abstract

Fourier transform infrared (FTIR) microspectroscopy and confocal imaging have been used to demonstrate that the neutral rhenium(I) tricarbonyl 1,10-phenanthroline complex bound to 4-cyanophenyltetrazolate as the ancillary ligand is able to localise in regions with high concentrations of polar lipids such as phosphatidylethanolamine (PE), sphingomyelin, sphingosphine and lysophosphatidic acid (LPA) in mammalian adipocytes.

This article is part of the themed collection: Chemical Biology in Molecular BioSystems

Molecular BioSystems

Unprecedented staining of polar lipids by a luminescent rhenium complex revealed by FTIR microspectroscopy in adipocytes†

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Unprecedented staining of polar lipids by a luminescent rhenium complex revealed by FTIR microspectroscopy in adipocytes

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