Issue 34, 2017
From the journal:

Polymer Chemistry

Poly(N-(2-hydroxypropyl)methacrylamide)–valproic acid conjugates as block copolymer nanocarriers†

Jawaher A. Alfurhood,a   Hao Sun, ORCID logo a   Christopher P. Kabb, ORCID logo a   Bryan S. Tucker,a   James H. Matthews,b   Hendrik Lueschb  and  Brent S. Sumerlin ORCID logo *a  

* Corresponding authors

a George & Josephine Butler Polymer Research Laboratory, Center for Macromolecular Science & Engineering, Department of Chemistry, University of Florida, PO Box 117200, Gainesville, FL 32611-7200, USA
E-mail: sumerlin@chem.ufl.edu
Fax: +1 352 392 9741

b Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, Gainesville, FL, USA

Abstract

We report nanoassemblies based on block copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) in which drug cleavage enhances the biological compatibility of the original polymer carrier by regeneration of HPMA units. Drug release via ester hydrolysis suggests this approach offers potential for stimuli-responsive drug delivery under acidic conditions.

Graphical abstract: Poly(N-(2-hydroxypropyl)methacrylamide)–valproic acid conjugates as block copolymer nanocarriers

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Article information

DOI
https://doi.org/10.1039/C7PY00196G
Article type
Communication
Submitted
02 Febr. 2017
Accepted
12 Febr. 2017
First published
22 Febr. 2017

Polym. Chem., 2017,8, 4983-4987

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Poly(N-(2-hydroxypropyl)methacrylamide)–valproic acid conjugates as block copolymer nanocarriers

J. A. Alfurhood, H. Sun, C. P. Kabb, B. S. Tucker, J. H. Matthews, H. Luesch and B. S. Sumerlin, Polym. Chem., 2017, 8, 4983 DOI: 10.1039/C7PY00196G

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