A cyanine-based fluorescent cassette with aggregation-induced emission for sensitive detection of pH changes in live cells

Mingxi Fang; Shuai Xia; Jianheng Bi; Travis P. Wigstrom; Loredana Valenzano; Jianbo Wang; Wafa Mazi; Marina Tanasova; Fen-Tair Luo; Haiying Liu

doi:10.1039/C7CC08986D

A cyanine-based fluorescent cassette with aggregation-induced emission for sensitive detection of pH changes in live cells†

Mingxi Fang,^a Shuai Xia,^a Jianheng Bi,^a Travis P. Wigstrom,^a Loredana Valenzano,*^a Jianbo Wang,*^ac Wafa Mazi,^a Marina Tanasova,

*^a Fen-Tair Luo*^b and Haiying Liu

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA
E-mail: hyliu@mtu.edu, mtanasov@mtu.edu

^b Institute of Chemistry, Academia Sinica, Taipei, Taiwan 11529, Republic of China
E-mail: luoft@gate.sinica.edu.tw

^c College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China
E-mail: wjb4207@mail.ustc.edu.cn

Abstract

An aggregation-induced emission (AIE) cyanine-based fluorescent cassette with a large pseudo-Stokes shift was designed and prepared to sensitively image pH changes in live cells via through-bond energy transfer (TBET) from a tetraphenylethene (TPE) donor to a cyanine acceptor.

This article is part of the themed collection: 20th Anniversary of Aggregation-Induced Emission

Chemical Communications

A cyanine-based fluorescent cassette with aggregation-induced emission for sensitive detection of pH changes in live cells†

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A cyanine-based fluorescent cassette with aggregation-induced emission for sensitive detection of pH changes in live cells

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