A divergent and concise total synthesis of (−)-lycoposerramine R and (+)-lycopladine A

Abstract

A concise, asymmetric and divergent synthesis of lycoposerramine R and lycopladine A is presented. The synthesis features the palladium-catalyzed cycloalkenylation of a silyl enol ether for assembling the 5/6-hydrindane system and generating a quaternary carbon center in one step.