Issue 27, 2018
From the journal:

CrystEngComm

Cocrystal formation by ionic liquid-assisted grinding: case study with cocrystals of caffeine†

Arijit Mukherjee, ORCID logo a   Robin D. Rogers ORCID logo b  and  A. S. Myerson ORCID logo *a  

* Corresponding authors

a Novartis-MIT Center for Continuous Manufacturing, and Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
E-mail: myerson@mit.edu

b 525 Solutions, Inc., P.O. Box 2206, Tuscaloosa, AL 35403, USA

Abstract

Liquid assisted grinding using imidazolium-based ionic liquids (IL-AG) was found to be effective in isolation of cocrystals and cocrystal polymorphs. Isolation of specific polymorphs of caffeine–citric acid (CAF–CA) and caffeine–glutaric acid (CAF–GLU) cocrystals highlights the tunability of ILs in polymorphic control.

Graphical abstract: Cocrystal formation by ionic liquid-assisted grinding: case study with cocrystals of caffeine

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Article information

DOI
https://doi.org/10.1039/C8CE00859K
Article type
Communication
Submitted
23 Maijs 2018
Accepted
12 Jūn. 2018
First published
20 Jūn. 2018
This article is Open Access
Creative Commons BY-NC license

CrystEngComm, 2018,20, 3817-3821

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Cocrystal formation by ionic liquid-assisted grinding: case study with cocrystals of caffeine

A. Mukherjee, R. D. Rogers and A. S. Myerson, CrystEngComm, 2018, 20, 3817 DOI: 10.1039/C8CE00859K

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