Methylene violet 3RAX-conjugated porphyrin for photodynamic therapy: synthesis, DNA photocleavage, and cell study

Si Yao; Yunman Zheng; Lijun Jiang; Chen Xie; Fengshou Wu; Chi Huang; Xiong Zhang; Ka-Leung Wong; Zaoying Li; Kai Wang

doi:10.1039/C7RA13176C

Methylene violet 3RAX-conjugated porphyrin for photodynamic therapy: synthesis, DNA photocleavage, and cell study†

Si Yao,‡^ac Yunman Zheng,‡^b Lijun Jiang,^d Chen Xie,^d Fengshou Wu,

*^c Chi Huang,

*^b Xiong Zhang,^c Ka-Leung Wong,

*^de Zaoying Li^b and Kai Wang*^a

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* Corresponding authors

^a Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, College of Chemistry and Chemical Engineering, Hubei University, Wuhan, P. R. China
E-mail: kaiwang@hubu.edu.cn

^b College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, P. R. China
E-mail: chihuang@whu.edu.cn

^c Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan, P. R. China
E-mail: wfs42@126.com

^d Department of Chemistry, Hong Kong Baptist University, Hong Kong, P. R. China
E-mail: klwong@hkbu.edu.hk

^e Changshu HKBU Technology Company Limited, Jiangsu Province, China

Abstract

A methylene violet 3RAX-conjugated porphyrin has been designed and synthesized as a potential photosensitizer in photodynamic therapy because of its high DNA binding constant and the efficacy in inhibiting cancer cells with subcellular localization.

This article is part of the themed collection: Editors’ collection: Photodynamic therapy

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Methylene violet 3RAX-conjugated porphyrin for photodynamic therapy: synthesis, DNA photocleavage, and cell study†

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Methylene violet 3RAX-conjugated porphyrin for photodynamic therapy: synthesis, DNA photocleavage, and cell study

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