Issue 88, 2019
From the journal:

Chemical Communications

Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material†

Wei-Tao Dou,‡a   Li-Fang Liu,‡ab   Jie Gao,ab   Yi Zang,*b   Guo-Rong Chen,a   Robert A. Field, ORCID logo c   Tony D. James, ORCID logo d   Jia Li*b  and  Xiao-Peng He ORCID logo *a  

* Corresponding authors

a Key Laboratory for Advanced Materials, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd, Shanghai 200237, China
E-mail: xphe@ecust.edu.cn

b National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shoujing Rd, Shanghai 201203, P. R. China
E-mail: yzang@simm.ac.cn, jli@simm.ac.cn

c Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK

d Department of Chemistry, University of Bath, Bath, UK

Abstract

Protein C receptor (PROCR) is a recently discovered transmembrane biomarker for several tissue stem cells and is highly expressed in triple-negative breast cancer (TNBC) patient-derived xenografts. Herein, to enrich the toolbox for the biochemical evaluation of PROCR, we have developed a peptide-functionalized fluorogenic 2D material based on the self-assembly between a fluorescent peptide probe and thin-layer molybdenum disulfide. The material developed was suitable for the sensitive detection of PROCR recombinant protein in buffer solution and the fluorescence imaging of TNBC cells that express high levels of PROCR.

Graphical abstract: Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material

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Article information

DOI
https://doi.org/10.1039/C9CC06399D
Article type
Communication
Submitted
18 Aug. 2019
Accepted
20 Sept. 2019
First published
02 Okt. 2019
This article is Open Access
Creative Commons BY license

Chem. Commun., 2019,55, 13235-13238

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Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material

W. Dou, L. Liu, J. Gao, Y. Zang, G. Chen, R. A. Field, T. D. James, J. Li and X. He, Chem. Commun., 2019, 55, 13235 DOI: 10.1039/C9CC06399D

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