Co-crystallization and polymorphic behaviour of 5-fluorouracil

Dennis D. Enkelmann; Jens Handelmann; Carsten Schauerte; Klaus Merz

doi:10.1039/C8CE01692E

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Co-crystallization and polymorphic behaviour of 5-fluorouracil†

Dennis D. Enkelmann,^a Jens Handelmann,^b Carsten Schauerte^c and Klaus Merz

*^b

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* Corresponding authors

^a Institute of Pharmacy, University of Innsbruck, Innrain 52c, 6020 Innsbruck, Austria

^b Inorganic Chemistry I – Bioinorganic Chemistry, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Universitätsstrasse 150, 44797 Bochum, Germany
E-mail: Klaus.merz@rub.de

^c Solid-Chem GmbH, Universitätstrasse 136, 44799 Bochum, Germany

Abstract

Syntheses and single-crystal characterization of two co-crystalline 5-fluorouracil compounds with nontoxic co-formers of the GRAS list, succinic acid and adipic acid, are presented. Furthermore, the target-oriented synthon approach from methanol or ethanol (technical grade) to polymorphic form II, which is hitherto only accessible from dry nitromethane, is described.

This article is part of the themed collection: The Solid State of Pharmaceuticals

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DOI: https://doi.org/10.1039/C8CE01692E
Article type: Paper
Submitted: 05 Okt. 2018
Accepted: 12 Nov. 2018
First published: 13 Nov. 2018

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CrystEngComm, 2019,21, 2130-2134

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Co-crystallization and polymorphic behaviour of 5-fluorouracil

D. D. Enkelmann, J. Handelmann, C. Schauerte and K. Merz, CrystEngComm, 2019, 21, 2130 DOI: 10.1039/C8CE01692E

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CrystEngComm

Co-crystallization and polymorphic behaviour of 5-fluorouracil†

Abstract

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Co-crystallization and polymorphic behaviour of 5-fluorouracil

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