Copper mediated C(sp2)–H amination and hydroxylation of phosphinamides

Shang-Zheng Sun; Ming Shang; Hui Xu; Tai-Jin Cheng; Ming-Hong Li; Hui-Xiong Dai

doi:10.1039/C9CC08879B

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Copper mediated C(sp²)–H amination and hydroxylation of phosphinamides†

Shang-Zheng Sun,

‡^a Ming Shang,‡^b Hui Xu,^c Tai-Jin Cheng,^c Ming-Hong Li^c and Hui-Xiong Dai

*^c

Author affiliations

* Corresponding authors

^a Department of Chemistry, Innovative Drug Research Center, Shanghai University, 99 Shangda Road, Shanghai, China

^b Department of Chemistry, The Scripps Research Institute, 10550N. Torrey Pines Road, La Jolla, California 92037, USA

^c Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, China
E-mail: hxdai@simm.ac.cn

Abstract

Copper mediated C(sp²)–H amination and hydroxylation of arylphosphinic acid are accomplished by adopting phosphinamide as the directing group. This method is distinguished by its wide substrate scope and excellent functional group tolerance, thus allowing for the rapid preparation of organophosphorus compounds in organic synthesis.

This article is part of the themed collection: Organic Synthesis

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Article information

DOI: https://doi.org/10.1039/C9CC08879B
Article type: Communication
Submitted: 13 Nov. 2019
Accepted: 20 Dec. 2019
First published: 21 Dec. 2019

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Chem. Commun., 2020,56, 1444-1447

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Copper mediated C(sp²)–H amination and hydroxylation of phosphinamides

S. Sun, M. Shang, H. Xu, T. Cheng, M. Li and H. Dai, Chem. Commun., 2020, 56, 1444 DOI: 10.1039/C9CC08879B

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