Self-assembling purine and pteridine quartets: how do π-conjugation patterns affect resonance-assisted hydrogen bonding?

Abstract

Computed association strengths for 43 purine and pteridine quartets (38 to 100 kcal mol⁻¹) show excellent linear correlation with π-conjugation gain in the assembled monomers (r² = 0.965). Even quartets having the same secondary electrostatic interactions can display very different association strengths depending on the π-conjugation patterns of the monomeric units.