Automated access to well-defined ionic oligosaccharides†
Yuntao
Zhu, 
a
Theodore
Tyrikos-Ergas,
ab
Andrea
Grafmüller,
c
Peter H.
Seeberger
ab
and
Martina
Delbianco
*a
a
Theodore
Tyrikos-Ergas,
ab
Andrea
Grafmüller,
c
Peter H.
Seeberger
ab
and
Martina
Delbianco
*a
Abstract
Ionic polysaccharides are part of many biological events, but lack structural characterisation due to challenging purifications and complex synthesis. Four monosaccharides bearing modifications not found in nature are used for the automated synthesis of a collection of ionic oligosaccharides. Structural analysis reveals how the charge pattern affects glycan conformation.
- This article is part of the themed collections: Chemical Biology in OBC and Glycosylation: New methodologies and applications
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