Efficient and selective antibody modification with functionalised divinyltriazines†
Andrew J.
Counsell, 
a
Stephen J.
Walsh,
a
Naomi S.
Robertson,
a
Hannah F.
Sore
a
and
David R.
Spring
*a
a
Stephen J.
Walsh,
a
Naomi S.
Robertson,
a
Hannah F.
Sore
a
and
David R.
Spring
*a
Abstract
A highly efficient disulfide rebridging strategy for the modification of monoclonal antibodies with substituted divinyltriazine linkers is reported. The reaction proceeds efficiently under mild conditions with near stoichiometric quantities of linker. This method of conjugation yields serum stable antibody conjugates with a controlled payload loading of 4.
- This article is part of the themed collections: Chemical Biology in OBC and Methodology development for protein modifications
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