Direct access to multi-functionalized benzenes via [4 + 2] annulation of α-cyano-β-methylenones and α,β-unsaturated aldehydes

Qianfa Jia; Yunfei Lan; Xin Ye; Yinhe Lin; Qiao Ren

doi:10.1039/D0RA05251E

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Direct access to multi-functionalized benzenes via [4 + 2] annulation of α-cyano-β-methylenones and α,β-unsaturated aldehydes†

Qianfa Jia,

^a Yunfei Lan,^b Xin Ye,^b Yinhe Lin*^a and Qiao Ren

*^b

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* Corresponding authors

^a Chongqing Key Laboratory of Inorganic Special Functional Materials, College of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling, Chongqing 408100, P. R. China

^b College of Pharmaceutical Science, Southwest University, Chongqing 400715, P. R. China

Abstract

An efficient [4 + 2] benzannulation of α-cyano-β-methylenones and α,β-unsaturated aldehydes was achieved under metal-free reaction conditions selectively delivering a wide range of polyfunctional benzenes in high yields respectively (up to 94% yield).

This article is part of the themed collection: 2020 RSC Advances HOT Article Collection

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DOI: https://doi.org/10.1039/D0RA05251E
Article type: Paper
Submitted: 15 Jūn. 2020
Accepted: 28 Jūl. 2020
First published: 06 Aug. 2020
This article is Open Access

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RSC Adv., 2020,10, 29171-29174

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Direct access to multi-functionalized benzenes via [4 + 2] annulation of α-cyano-β-methylenones and α,β-unsaturated aldehydes

Q. Jia, Y. Lan, X. Ye, Y. Lin and Q. Ren, RSC Adv., 2020, 10, 29171 DOI: 10.1039/D0RA05251E

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Direct access to multi-functionalized benzenes via [4 + 2] annulation of α-cyano-β-methylenones and α,β-unsaturated aldehydes†

Abstract

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Direct access to multi-functionalized benzenes via [4 + 2] annulation of α-cyano-β-methylenones and α,β-unsaturated aldehydes

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