Towards optimizing peptide-based inhibitors of protein–protein interactions: predictive saturation variation scanning (PreSaVS)

Kristina Hetherington; Som Dutt; Amaurys A. Ibarra; Emma E. Cawood; Fruzsina Hobor; Derek N. Woolfson; Thomas A. Edwards; Adam Nelson; Richard B. Sessions; Andrew J. Wilson

doi:10.1039/D1CB00137J

Towards optimizing peptide-based inhibitors of protein–protein interactions: predictive saturation variation scanning (PreSaVS)†

Kristina Hetherington,‡^ab Som Dutt,‡^ab Amaurys A. Ibarra,‡^c Emma E. Cawood,

^ab Fruzsina Hobor,^ad Derek N. Woolfson,

^cef Thomas A. Edwards,

^ad Adam Nelson,

^ab Richard B. Sessions

*^cf and Andrew J. Wilson

*^ab

Author affiliations

* Corresponding authors

^a Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK
E-mail: a.j.wilson@leeds.ac.uk

^b School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK

^c School of Biochemistry, University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 1TD, UK
E-mail: r.sessions@bristol.ac.uk

^d School of Molecular and Cellular Biology, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK

^e School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK

^f BrisSynBio, University of Bristol, Life Sciences Building, Tyndall Avenue, Bristol BS8 1TQ, UK

Abstract

A simple-to-implement and experimentally validated computational workflow for sequence modification of peptide inhibitors of protein–protein interactions (PPIs) is described.

This article is part of the themed collection: RSC Chemical Biology Transparent Peer Review Collection

RSC Chemical Biology

Towards optimizing peptide-based inhibitors of protein–protein interactions: predictive saturation variation scanning (PreSaVS)†

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Towards optimizing peptide-based inhibitors of protein–protein interactions: predictive saturation variation scanning (PreSaVS)

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