Electrochemical synthesis of sulfamides

Abstract

Herein we demonstrate the first electrochemical synthesis protocol of symmetrical sulfamides directly from anilines and SO₂ mediated by iodide. Sulfamides are an emerging functional group in drug design. Highlights are the direct use of SO₂ from a stock solution and no necessity of any supporting electrolyte. Overall, the reaction has been demonstrated for 15 examples with yields up to 93%.