Recent progress in the oxidative coupling of unactivated Csp3–H bonds with other C–H bonds

Abstract

The oxidative coupling between two carbon–hydrogen (C–H) bonds offers the most straightforward pathway to construct C–C bonds from hydrocarbons without pre-functionalization, exhibiting high step- and atom-economy. This article features the recent advances in the oxidative coupling of unactivated Csp³–H with different hybrid C–H bonds, including Csp–H, Csp²–H and Csp³–H bonds. The substrate scope, proposed mechanism and application of these reactions are summarized, intending to provide insights toward developing novel and efficient protocols for Csp³–C bond construction.