Issue 93, 2021
From the journal:

Chemical Communications

Harnessing stress granule formation by small molecules to inhibit the cellular replication of SARS-CoV-2†

Wan Gi Byun,a   Jihye Lee,b   Seungtaek Kimb  and  Seung Bum Park ORCID logo *a  

* Corresponding authors

a CRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Seoul, Korea
E-mail: sbpark@snu.ac.kr

b Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam 13488, Korea

Abstract

We identified small-molecule enhancers of cellular stress granules by observing molecular crowding of proteins and RNAs in a time-dependent manner. Hit molecules sensitized the IRF3-mediated antiviral mechanism in the presence of poly(I:C) and inhibited the replication of SARS-CoV-2 by inducing stress granule formation. Thus, modulating multimolecular crowding can be a promising strategy against SARS-CoV-2.

Graphical abstract: Harnessing stress granule formation by small molecules to inhibit the cellular replication of SARS-CoV-2

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Article information

DOI
https://doi.org/10.1039/D1CC05508A
Article type
Communication
Submitted
30 Sept. 2021
Accepted
22 Okt. 2021
First published
26 Okt. 2021
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2021,57, 12476-12479

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Harnessing stress granule formation by small molecules to inhibit the cellular replication of SARS-CoV-2

W. G. Byun, J. Lee, S. Kim and S. B. Park, Chem. Commun., 2021, 57, 12476 DOI: 10.1039/D1CC05508A

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