Variable stoichiometry cocrystals: occurrence and significance

Abstract

The occurrence of variable stoichiometry cocrystals offers the prospect to acquire more solid forms of the same system. The control of stoichiometry is extremely important concerning purity and intellectual property (IP) protection. We have analysed structures, synthetic methodologies and properties of the reported variable stoichiometry organic cocrystals reported in the last decade, with discussion of their controlled production for drug formulation plans. This review further fetches an understanding of the accountable reasons for the existence of stoichiometry variation in cocrystals, which essentially results from the disparity in properties with IP coverage.