Additive manufacturing of multielectrode arrays for biotechnological applications

Amelia V. Edwards; Christopher Hann; Henry Ivill; Hanna Leeson; Larysa Tymczyszyn; Damian M. Cummings; Mark D. Ashton; Garry R. Harper; Diane T. Spencer; Wan Li Low; Kiron Rajeev; Pierre Martin-Hirsch; Frances A. Edwards; John G. Hardy; Allan E. W. Rennie; David Cheneler

doi:10.1039/D0MA00484G

Additive manufacturing of multielectrode arrays for biotechnological applications†

Amelia V. Edwards,‡^a Christopher Hann,‡^a Henry Ivill,‡^a Hanna Leeson,‡^a Larysa Tymczyszyn,‡^a Damian M. Cummings,

^b Mark D. Ashton,

^c Garry R. Harper,

^c Diane T. Spencer,^d Wan Li Low,

^e Kiron Rajeev,^f Pierre Martin-Hirsch,^g Frances A. Edwards,

*^b John G. Hardy,

*^ch Allan E. W. Rennie

*^a and David Cheneler

*^ah

Author affiliations

* Corresponding authors

^a Department of Engineering, Lancaster University, Lancaster, UK
E-mail: a.rennie@lancaster.ac.uk, d.cheneler@lancaster.ac.uk

^b Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
E-mail: f.a.edwards@ucl.ac.uk

^c Department of Chemistry, Lancaster University, Lancaster, UK
E-mail: j.g.hardy@lancaster.ac.uk

^d Rosalind Franklin Building, Faculty of Science and Engineering, University of Wolverhampton, Stafford Street, Wolverhampton, West Midlands, UK

^e School of Pharmacy, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, West Midlands, UK

^f NeuDrive Ltd, National Printable Electronics Centre, NETPark, County Durham, UK

^g Lancashire Teaching Hospitals NHS Trust, Royal Preston Hospital, Sharoe Green Lane, Preston, UK

^h Materials Science Institute, Lancaster University, Lancaster, UK

Abstract

Multielectrode arrays (MEAs) are electrical devices that transduce (record/deliver) cellular voltage signals. Commercially available MEAs are expensive and here we provide proof of concept for the application of an additive manufacturing approach to prepare inexpensive MEAs and demonstrate their ability to interact with brain tissue ex vivo.

This article is part of the themed collection: Celebrating Materials Science in the UK

Materials Advances

Additive manufacturing of multielectrode arrays for biotechnological applications†

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