Metabolically engineered bacteria as light-controlled living therapeutics for anti-angiogenesis tumor therapy

Xingang Liu; Min Wu; Meng Wang; Yukun Duan; ChiUyen Phan; Guobin Qi; Guping Tang; Bin Liu

doi:10.1039/D0MH01582B

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Metabolically engineered bacteria as light-controlled living therapeutics for anti-angiogenesis tumor therapy†

Xingang Liu,‡^a Min Wu,‡^a Meng Wang,^b Yukun Duan,^a ChiUyen Phan,^c Guobin Qi,^a Guping Tang

*^c and Bin Liu

*^ad

Author affiliations

* Corresponding authors

^a Department of Chemical and Biomolecular Engineering, National University of Singapore, Engineering Drive 4, Singapore
E-mail: cheliub@nus.edu.sg

^b Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou 310003, China

^c Department of Chemistry, Zhejiang University, Hangzhou 310028, China
E-mail: tangguping@zju.edu.cn

^d Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Binhai New City, Fuzhou 350207, China

Abstract

A living therapeutic system based on attenuated Salmonella was developed via metabolic engineering using an aggregation-induced emission (AIE) photosensitizer MA. The engineered bacteria could localize in the tumor tissues and continue to colonize and express exogenous genes. Under light irradiation, the encoded VEGFR2 gene was released and expressed in tumor tissues, which can suppress angiogenesis induced by a T cell-mediated autoimmune response and inhibit tumor growth.

This article is part of the themed collections: Celebrating International Women’s Day: Women in Materials Science and 2021 Materials Horizons Advisory Board collection

Download options Please wait...

Supplementary files

Supplementary information PDF (2134K)

Article information

DOI: https://doi.org/10.1039/D0MH01582B
Article type: Communication
Submitted: 04 Okt. 2020
Accepted: 15 Dec. 2020
First published: 16 Dec. 2020

Download Citation

Mater. Horiz., 2021,8, 1454-1460

Permissions

Request permissions

Metabolically engineered bacteria as light-controlled living therapeutics for anti-angiogenesis tumor therapy

X. Liu, M. Wu, M. Wang, Y. Duan, C. Phan, G. Qi, G. Tang and B. Liu, Mater. Horiz., 2021, 8, 1454 DOI: 10.1039/D0MH01582B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Materials Horizons

Metabolically engineered bacteria as light-controlled living therapeutics for anti-angiogenesis tumor therapy†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Metabolically engineered bacteria as light-controlled living therapeutics for anti-angiogenesis tumor therapy

Social activity

Search articles by author

Spotlight

Advertisements