Boron-rich, cytocompatible block copolymer nanoparticles by polymerization-induced self-assembly

Lin-Chiang Sherlock Huang; Dao Le; I-Lun Hsiao; Susanne Fritsch-Decker; Christian Hald; Su-Ching Huang; Jen-Kun Chen; Jih Ru Hwu; Carsten Weiss; Min-Hua Hsu; Guillaume Delaittre

doi:10.1039/D0PY00710B

Boron-rich, cytocompatible block copolymer nanoparticles by polymerization-induced self-assembly†

Lin-Chiang Sherlock Huang,‡^abc Dao Le,

‡^abd I-Lun Hsiao,^ef Susanne Fritsch-Decker,^e Christian Hald,^ab Su-Ching Huang,^g Jen-Kun Chen,

^g Jih Ru Hwu,

^c Carsten Weiss,

^e Min-Hua Hsu

*^h and Guillaume Delaittre

*^abi

Author affiliations

* Corresponding authors

^a Institute of Biological and Chemical Systems – Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany

^b Institute for Chemical Technology and Polymer Chemistry (ITCP), Karlsruhe Institute of Technology (KIT), Engesserstrasse 15, 76131 Karlsruhe, Germany

^c Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan

^d Polymer Chemistry Team (ECP), Institut Parisien de Chimie Moléculaire (IPCM), Sorbonne Université and CNRS, UMR 8232, 4 Place Jussieu, 75005 Paris, France

^e Institute of Biological and Chemical Systems – Biological Information Processing (IBCS-BIP), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany

^f School of Food Safety, College of Nutrition, Taipei Medical University, No. 250, Wuxing St., Taipei 11031, Taiwan

^g Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, No. 35, Keyan Rd., Zhunan Township, Miaoli County 35053, Taiwan

^h Department of Chemistry, National Changhua University of Education, Changhua 50007, Taiwan
E-mail: minghuahsu@cc.ncue.edu.tw

ⁱ Organic Functional Molecules, Organic Chemistry, University of Wuppertal, Gaußstrasse 20, 42119 Wuppertal, Germany
E-mail: delaittre@uni-wuppertal.de
Web: http://www.twitter.com/GPRDelaittre

Abstract

Core–shell nanoparticles (NPs) with a boron-rich core were synthesized by RAFT-mediated polymerization-induced self-assembly using a new methacrylic boronate ester monomer. Under specific conditions, sub-100 nm spherical NPs could be obtained at high conversions by either emulsion or dispersion RAFT polymerization using poly(oligo(ethylene glycol) methacrylate) (POEGMA) dithiobenozate-based chain transfer agents. Phenylboronic acid surface-functionalized NPs were obtained using a telechelic POEGMA. Primary data on biocompatibility is provided and suggests suitability as boron delivery agent for boron neutron capture therapy.

This article is part of the themed collection: Polymerization-Induced Self-Assembly (PISA)

Polymer Chemistry

Boron-rich, cytocompatible block copolymer nanoparticles by polymerization-induced self-assembly†

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Boron-rich, cytocompatible block copolymer nanoparticles by polymerization-induced self-assembly

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