Copper-catalyzed three-component oxycyanation of alkenes

Yuehua Zeng; Yajun Li; Daqi Lv; Hongli Bao

doi:10.1039/D0QO01437K

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Copper-catalyzed three-component oxycyanation of alkenes†

Yuehua Zeng,^a Yajun Li,

^a Daqi Lv^a and Hongli Bao

*^ab

Author affiliations

* Corresponding authors

^a Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, State Key Laboratory of Structural Chemistry, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, University of Chinese Academy of Sciences, 155 Yangqiao Road West, Fuzhou, Fujian 350002, P. R. China
E-mail: hlbao@fjirsm.ac.cn

^b University of Chinese Academy of Sciences, Beijing, P. R. China

Abstract

A copper-catalyzed, three-component reaction for the direct oxycyanation of various alkenes with aryl diacyl peroxides and trimethylsilyl cyanide has been developed. Both unactivated alkenes and styrenes are reliable substrates and produce β-cyanohydrin derivatives. An asymmetric version of this reaction has been conducted and proceeds well.

This article is part of the themed collection: FOCUS: Radical-involved chemical transformations

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DOI: https://doi.org/10.1039/D0QO01437K
Article type: Research Article
Submitted: 18 Nov. 2020
Accepted: 22 Dec. 2020
First published: 25 Dec. 2020

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Org. Chem. Front., 2021,8, 908-914

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Copper-catalyzed three-component oxycyanation of alkenes

Y. Zeng, Y. Li, D. Lv and H. Bao, Org. Chem. Front., 2021, 8, 908 DOI: 10.1039/D0QO01437K

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Copper-catalyzed three-component oxycyanation of alkenes†

Abstract

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Copper-catalyzed three-component oxycyanation of alkenes

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