Impact of molecular rigidity on the gene delivery efficiency of core–shell tecto dendrimers

Dayuan Wang; Liang Chen; Yue Gao; Cong Song; Zhijun Ouyang; Changsheng Li; Serge Mignani; Jean-Pierre Majoral; Xiangyang Shi; Mingwu Shen

doi:10.1039/D1TB01328A

Impact of molecular rigidity on the gene delivery efficiency of core–shell tecto dendrimers†

Dayuan Wang,^a Liang Chen,^a Yue Gao,^a Cong Song,^a Zhijun Ouyang,^a Changsheng Li,^a Serge Mignani,^bc Jean-Pierre Majoral,

^de Xiangyang Shi

*^ab and Mingwu Shen

*^a

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* Corresponding authors

^a State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China
E-mail: mwshen@dhu.edu.cn, xshi@dhu.edu.cn

^b CQM-Centro de Quimica da Madeira, Universidade da Madeira, Funchal 9020-105, Portugal

^c Université Paris Descartes, PRES Sorbonne Paris Cité, CNRS UMR 860, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologique, 45, rue des Saints Peres, Paris 75006, France

^d Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, Toulouse Cedex 4, France

^e Université Toulouse 118 route de Narbonne, Toulouse Cedex 4, France

Abstract

We report the construction of two types of core–shell tecto dendrimers (CSTDs) with different core rigidities to illustrate the impact of molecular rigidity on their gene delivery efficiency. Our study reveals that CSTDs designed with rigid cores enable promoted gene delivery, providing many possibilities for a wide range of gene delivery-associated biomedical applications.

This article is part of the themed collection: Journal of Materials Chemistry B HOT Papers

Journal of Materials Chemistry B

Impact of molecular rigidity on the gene delivery efficiency of core–shell tecto dendrimers†

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Impact of molecular rigidity on the gene delivery efficiency of core–shell tecto dendrimers

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