Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide

^a Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, Spain
E-mail: eugenio.vazquez@usc.es

^b Insilichem, Departament de Química, Universitat Autònoma de Barcelona, 08193 Cerdanyola, Spain

^c Department of Inorganic, Organic Chemistry and Biochemistry, Faculty of Pharmacy, University of Castilla-La Mancha, 02071 Albacete, Spain

^d Regional Center for Biomedical Research (CRIB), 02071 Albacete, Spain

^e Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Bioquímica y Biología Molecular, Universidade de Santiago de Compostela, Spain

^f Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Inorgánica, Universidade de Santiago de Compostela, Spain

Abstract

Non-canonical DNA structures, particularly 3-Way Junctions (3WJs) that are transiently formed during DNA replication, have recently emerged as promising chemotherapeutic targets. Here, we describe a new approach to target 3WJs that relies on the cooperative and sequence-selective recognition of A/T-rich duplex DNA branches by three AT-Hook peptides attached to a three-fold symmetric and fluorogenic 1,3,5-tristyrylbenzene core.

This article is part of the themed collection: 2022 Pioneering Investigators

Chemical Communications

Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide†

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Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide

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