Hydrogen-bonded supramolecular polymer micelles with pH/photothermal-responsive carmofur release and combined chemo-photothermal therapy

Yanggui Wu; Huiying Wang; Qianqian Liu; Frédéric Lortie; Julien Bernard; Wolfgang H. Binder; Senbin Chen; Jintao Zhu

doi:10.1039/D1PY01634B

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Hydrogen-bonded supramolecular polymer micelles with pH/photothermal-responsive carmofur release and combined chemo-photothermal therapy†

Yanggui Wu,‡^a Huiying Wang,‡^a Qianqian Liu,^b Frédéric Lortie,^c Julien Bernard,

^c Wolfgang H. Binder,

^d Senbin Chen*^a and Jintao Zhu

*^a

Author affiliations

* Corresponding authors

^a Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan 430074, China
E-mail: jtzhu@mail.hust.edu.cn, senbin@hust.edu.cn

^b School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan, China

^c Univ Lyon, INSA Lyon, CNRS, IMP UMR 5223, Villeurbanne, France

^d Chair of Macromolecular Chemistry, Faculty of Natural Science II (Chemistry, Physics and Mathematics), Martin Luther University Halle-Wittenberg, von-Danckelmann-Platz 4, Halle (Saale) D-06120, Germany

Abstract

Integrating biomedical applications (e.g., drug delivery) into supramolecular chemistry is a promising strategy. This work targets the construction of hydrogen-bonded (H-bonded) supramolecular polymeric micelles loaded with chemotherapy drugs (carmofur) and photothermal agents (IR780) for combined chemo-photothermal therapies (CT/PTT).

This article is part of the themed collection: Polymer Chemistry Recent HOT Articles

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Article information

DOI: https://doi.org/10.1039/D1PY01634B
Article type: Communication
Submitted: 09 Dec. 2021
Accepted: 23 Janv. 2022
First published: 05 Febr. 2022

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Polym. Chem., 2022,13, 1010-1014

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Hydrogen-bonded supramolecular polymer micelles with pH/photothermal-responsive carmofur release and combined chemo-photothermal therapy

Y. Wu, H. Wang, Q. Liu, F. Lortie, J. Bernard, W. H. Binder, S. Chen and J. Zhu, Polym. Chem., 2022, 13, 1010 DOI: 10.1039/D1PY01634B

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Polymer Chemistry

Hydrogen-bonded supramolecular polymer micelles with pH/photothermal-responsive carmofur release and combined chemo-photothermal therapy†

Abstract

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Hydrogen-bonded supramolecular polymer micelles with pH/photothermal-responsive carmofur release and combined chemo-photothermal therapy

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