Rational design of a NIR fluorescent probe for carboxylesterase 1 detection during endoplasmic reticulum stress and drug-induced acute liver injury

Chaoyan Han; Xin Zhao; Xiaokui Huo; Zhenlong Yu; Chao Wang; Lei Feng; Jingnan Cui; Xiangge Tian; Xiaochi Ma

doi:10.1039/D2CC04237A

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Rational design of a NIR fluorescent probe for carboxylesterase 1 detection during endoplasmic reticulum stress and drug-induced acute liver injury†

Chaoyan Han,‡^ab Xin Zhao,‡^c Xiaokui Huo,

^a Zhenlong Yu,^b Chao Wang,

^b Lei Feng,

*^ade Jingnan Cui,

^c Xiangge Tian

*^a and Xiaochi Ma

*^af

Author affiliations

* Corresponding authors

^a Second Affiliated Hospital, Dalian Medical University, Dalian 116023, China

^b College of Pharmacy, Dalian Medical University, Dalian 116044, China

^c State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China

^d School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China

^e Key Laboratory of Emergency and Trauma, Ministry of Education, College of Emergency and Trauma, Hainan Medical University, Haikou 571199, China

^f Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China

Abstract

An endoplasmic reticulum targeting NIR fluorescent probe (ERBM) was developed for real-time monitoring of carboxylesterase 1 (CES1) and exhibited excellent ER location in living cell imaging. In addition, ERBM was applied to illustrate the regulation characteristics of CES1 under ER stress and acute liver injury models at the cell and animal level.

This article is part of the themed collection: Chemosensors and Molecular Logic

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Article information

DOI: https://doi.org/10.1039/D2CC04237A
Article type: Communication
Submitted: 29 Jūl. 2022
Accepted: 12 Dec. 2022
First published: 13 Dec. 2022

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Chem. Commun., 2023,59, 1145-1148

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Rational design of a NIR fluorescent probe for carboxylesterase 1 detection during endoplasmic reticulum stress and drug-induced acute liver injury

C. Han, X. Zhao, X. Huo, Z. Yu, C. Wang, L. Feng, J. Cui, X. Tian and X. Ma, Chem. Commun., 2023, 59, 1145 DOI: 10.1039/D2CC04237A

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Chemical Communications

Rational design of a NIR fluorescent probe for carboxylesterase 1 detection during endoplasmic reticulum stress and drug-induced acute liver injury†

Abstract

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Rational design of a NIR fluorescent probe for carboxylesterase 1 detection during endoplasmic reticulum stress and drug-induced acute liver injury

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