Lipid droplet targeting-guided hypoxic photodynamic therapy with curcumin analogs

Xuewei Li; Weimin Liu; Xiuli Zheng; Meiyu Jiang; Yimin Guo; Jie Sha; Jiasheng Wu; Haohui Ren; Honglei Gao; Shuai Wang; Pengfei Wang

doi:10.1039/D2CC07025A

Lipid droplet targeting-guided hypoxic photodynamic therapy with curcumin analogs†

Xuewei Li,^ab Weimin Liu,

*^ab Xiuli Zheng,

^ac Meiyu Jiang,^ab Yimin Guo,^ab Jie Sha,^ab Jiasheng Wu,^a Haohui Ren,^ac Honglei Gao,^ab Shuai Wang^ab and Pengfei Wang

*^ab

Author affiliations

* Corresponding authors

^a Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, People's Republic of China
E-mail: wmliu@mail.ipc.ac.cn, wangpf@mail.ipc.ac.cn

^b School of Future Technology, University of Chinese Academy of Sciences, Beijing, People's Republic of China

^c Institute of Optical Physics and Engineering Technology, Qilu Zhongke, Jinan, People's Republic of China

Abstract

Two photosensitizers (CCOH and CCN) were designed and synthesized by introducing coumarin into the curcumin (CUR) structure. Compared with CUR, more reactive oxygen species (ROS) were generated by CCOH and CCN in type I and II synergy upon light irradiation. Cell experiments indicated that CCN with an excellent LD-targeting effect could be used to monitor the changes in the morphology and number of LDs in tumor cells during PDT.

This article is part of the themed collection: Photofunctional Materials and Transformations

Chemical Communications

Lipid droplet targeting-guided hypoxic photodynamic therapy with curcumin analogs†

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