Concurrent tandem catalysis enabled by nanomechanical motion in heteroleptic four-component dual-catalyst machinery

Abstract

When the basic ligand 3 was added to the heteroleptic three-component slider-on-deck [Ag₃(1)(2)]³⁺ (sliding frequency k₂₉₈ = 57 kHz), it operated as a moderate brake pad (k₂₉₈ = 45 kHz). Due to motion in the resulting four-component slider-on-deck [Ag₃(1)(2)(3)]³⁺, both ligand 3 and silver(I) were continuously exposed and became catalytically active in a concurrent tandem Michael addition/hydroalkoxylation.