NDIPhos as a platform for chiral supramolecular ligands in rhodium-catalyzed enantioselective hydrogenation

Abstract

Chiral naphthalene diimide ligands (NDIPhos) were exploited in rhodium-catalyzed enantioselective hydrogenation. The key feature of these ligands is their ability to self-assemble via π–π interactions to mimic bidentate ligands, offering a complementary method to traditional supramolecular strategies. This concept was further substantiated by computations with the composite electronic-structure method r²SCAN-3c.