Ultra-selective 1D clean in-phase correlation spectroscopy†
Daniel A.
Taylor, 
a
Peter
Kiraly,
b
Paul
Bowyer,
c
Mathias
Nilsson,
a
Laura
Castañar,
ad
Gareth A.
Morris
a
and
Ralph W.
Adams
*a
a
Peter
Kiraly,
b
Paul
Bowyer,
c
Mathias
Nilsson,
a
Laura
Castañar,
ad
Gareth A.
Morris
a
and
Ralph W.
Adams
*a
Abstract
Selective 1D COSY can unambiguously identify coupled spins but is often limited both by lack of selectivity, and by unfavourable multiplet lineshapes. Here, ultra-selective GEMSTONE excitation is employed with CLIP-COSY to provide through-bond correlations for nuclei whose NMR signals overlap. The new method is illustrated using the coccidiostat lasalocid and the immunosuppressant cyclosporin.
- This article is part of the themed collections: Celebrating the scientific accomplishments of RSC Fellows and Celebrating the 200th Anniversary of the University of Manchester
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