Benchtop nickel-catalyzed reductive coupling of aldehydes with alkynes and ynamides

Abstract

We demonstrate the potential of Ni(COD)(DQ), a bench-stable Ni⁰ complex, as a catalyst for the reductive coupling of aldehydes with alkynes and ynamides, providing silylated allyl alcohols with excellent yields and regioselectivities. Mass spectrometric identification of the intermediates and DFT studies supported the proposed mechanism.